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Spells can be cast 100% further (doubling distance). In some cases a targeted monster will not even be able to figure out where the caster is -- or may not be able to reach the caster -- making the caster invulnerable to counterattack. Whereas some feats simply improve stats in ways that could also be accomplished by equipment or potions, Enlarge has an effect that is otherwise not available. Each spell cast while Enlarge is active costs 10 more spellpoints.
Spells not defined by distance or not of standard ranges are not affected.