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A exhausted creature takes a -50% penalty to movement speed, -6 penalty to Strength and Dexterity, and cannot tumble. May be cured completely by the spells Heal, (Greater) Restoration, or Panacea.
If cured by Lesser Restoration, Exhaustion is instead replaced with Fatigued
Exhaustion may be the result of an enemy spell cast on the player such as Waves of Exhaustion or Ray of Exhaustion (and you fail the save).