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Your Will save is a Saving Throw that details how well you are able to withstand mental effects. If you were targeted by a Hold Person or being charmed by a siren then you would roll a Will save against a specific DC or Difficulty Class to see if you are able to withstand the effect.
The Will save itself is primarily driven by how high your Wisdom Ability is.
Other saving throws are Fortitude save and Reflex save.