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Alignment in DDO is similar to the PnP alignment, except one cannot be evil. Thus the available alignments are:

[edit] Compatibility with weapon enhancements

Table: Alignments Compatibility with Weapon enhancements
Enhancement (damage type) Lawful Good Lawful Neutral Neutral Good True Neutral Chaotic Good Chaotic Neutral
Axiomatic (2d6 law) X X X X - -
Anarchic (2d6 chaos) - - X X X X
Holy (2d6 good) X X X X X X
Unholy (2d6 evil) - X - X - X
Evil burst (1d6 evil +3d6 per crit +d6 per crit x above x2) X X X X X X
Evil blast (3d6 evil per crit +d6 per crit x above x2 + 4d6 on a natural 20 + confirmation) X X X X X X
True law (1d6 law) X X - - - -
Absolute law (2d6 law) X X - - - -
True chaos (1d6 chaos) - - - - X X
Pure good (1d6 good) X - X - X -
Good burst (1d6 good +3d6 per crit +d6 per crit x above x2) X X X X X X
Good blast (3d6 good per crit +d6 per crit x above x2 + 4d6 on a natural 20 + confirmation) X X X X X X
Greater good (2d6 good) X - X - X -

[edit] Compatibility with armor enhancements and item enhancements

Table: Alignments Compatibility with Armor enhancements and item enhancements
Enhancement (bonus type) True Neutral Anything else
Stability (+2 deflection to AC, +2 resistance to saves) X -
Greater stability (+4 deflection to AC, +4 resistance to saves) X -
Taint of evil (Negative level for all good aligned characters) X -