Fireball

Tips
If you target an individual enemy, the ball will center on his current position at time of casting, allowing him time to move away before the explosion. Instead, try hitting the terrain he is moving towards. Compared to Burning Hands, Fireball has much more range, a fact that is less commonly needed in DDO than in PnP. Note that when Fireball is first available for you to add to your spell list, it will probably do less damage than your current Burning Hands spell, as you may have Combustion enhancements that boost level 1-2 fire spells. Only when you get higher-level enhancements (or alternatively, drop them completely) does Fireball become more damaging.

Be careful using Fireball on opponents who are trapped by the Web spell, as fire may remove the web, but not do enough damage to finish them off.