Named chest loot

These specific items are found in chests in certain missions (generally, the same chest each time). Unlike unique quest rewards, they are not bound to the player who received it. Some of these items will only appear if a certain named monster is randomly spawned.

Particularly important items in the following lists include Muckbane, the Chill Shard, the Fragment of Silver Flame, the Silver Bow, the Planar Gird, and Chaosgarde, all of which provide capabilities that are impossible to find elsewhere. Other notable items are the Giant Stalker Knife, Bloodplate, and the Lightning Rod, which have powerful abilities rarely found on random items.

Bring Me the Head of Ghola Fan Loot

 * Fellblade - +4 Falchion: Vertigo +4
 * Mystic Ring - Ring, Spell Penetration 5
 * Royal Guard Mask - Mask: Teleport 1x/rest
 * Stave of the Seer - +1 Quarterstaff, +2 Intelligence, +2 Wisdom, +5 Use Magic Device, True Seeing 1x/day

Caverns of Korromar Loot

 * Aberrant Robe - Robe: Spell resistance 17, Wizardry II
 * Chill Shard - +2 Throwing dagger: Frost, Returning
 * Disc of Enhancement - +3 Docent
 * Grudgebearer's Plate - +2 Full plate: Command
 * Mace of the Wraith - +2 Heavy mace: Ghost touch
 * Scarf of Warmth - Necklace: Lesser Cold resistance
 * Wight Hide - +2 Leather Armor: Silent moves, Shadow
 * Xoriat Forged Blade - +1 Longsword: Flaming, Anarchic

Chains of Flame Loot

 * Cape of the Roc - Cloak: Featherfalling, +6 strength 30 sec 3x/rest
 * Golden Greaves - Boots: 15% Striding, DR 3/- (Valgrim chest)
 * Hruvyaha's Medallion - Necklace: Spell Penetration VI, Taint of Evil (temporary negative level to good-aligned wearers) (end chest)
 * Ring of Bahomet - Ring: +11 Intimidate, -1 Wisdom, -1 Charisma (Valgrim chest)
 * Staff of Inner Sight - +2 Quarterstaff: +4 Intelligence
 * Unkor's Cleaver - +4 Battleaxe: Keen(vault chest)

Chamber of Raiyum Loot
These items appear in a single chest in the treasure chamber in the center of the tomb's lowest floor.
 * Adherent's Pendant - Necklace: Wizardry:Wizardy II, Superior Devotion IV, Paladin-only (UMD DC 12)
 * Bejeweled Letter Opener - +3 Dagger: Keen, Improved Resonance 4, Improved Devotion 4
 * Mysterious Ring - Ring: +3 Charisma, Moderate Fortification
 * Mysterious Ring - Ring: +3 Dexterity, Resistance +3
 * Mysterious Ring - Ring: +3 Constitution, Minor Spell Penetration VI
 * Mysterious Ring - Ring: +3 Strength, Protection +3
 * Silken Mail - +4 Chainmail: Mithral, Axeblock, Improved Silent Moves
 * Sirocco - +3 Longsword: Telekinetic, Sirocco
 * Vambraces of Inner Light - +3 Full plate: +3 Charisma, Command

The Church and The Cult (Vampire Chest) Loot

 * Bloodplate - +2 Full plate: Deathblock
 * Cloak of Shadows - Cloak: +7 Hide, +7 Move silently, +2 Protection
 * Shard of the Silver Flame - Trinket: Continuous Protection from evil
 * Silver Longbow - +2 Longbow (1d10/19-20): Holy

Cloven-Jaw Scourge: Caverns of Shaagh (Shan-To-Kor 2) Loot

 * Dhakaani Shield - +1 Heavy Wooden Shield
 * Robe of Resistance - Robe: +1 Resistance

The Crucible Loot

 * Aquatic Bracers - Bracers: Underwater Action, +13 Swim, Improved Cold Resistance
 * Backstabber's Gloves - Gloves: +10 Bluff, +2 Backstabbing
 * Daggertooth Belt - Belt: +3 Constitution, Enhancement: Fighter's Armor Mastery II
 * Ghost-Waking Cloak - Cloak: +3 Charisma, +3 Resistance
 * Surefooted Boots - Boots: +10 Balance, +20% Striding
 * Skullsmasher - +5 Light mace: Orc Bane, +10 Intimidate
 * Windlash - +5 Falcion: Screaming, Weapon Focus: Falcion

The Crypt of Gerard Dryden (Catacombs 4) Loot

 * Battleworn Sword - +1 Greatsword: Ghost Touch
 * Gerard Dryden's Mace - +1 Heavy mace: Undead bane
 * Gerard's Mail - Masterwork Chain Shirt: Mithril

Durk's Got a Secret Loot

 * Muckbane - +1 Club: Lesser Ooze Bane, Glass
 * Periapt of Health - Trinket: Immunity to disease
 * Rahkat's Trifle -- Trinket: +1 Charisma
 * Zizoo's Spangle - Trinket: +1 Intelligence

Garrison's missing pack Loot

 * Furor's hide - Cloak: Lesser Axeblock
 * Kutik's Bead - Trinket: +1 Strength
 * Miasma's Fang - +1 Dagger: +1 Fort Save, Deception
 * Moog's Ornament - Trinket: +1 Dexterity
 * Peridot Ring - Ring: +2 Will save

Gianthold Tor Loot

 * Allegiance - +5 Khopesh: Elf Bane, Khopesh Proficiency (Black Dragon chest)
 * Belt of the Seven Ideals - Belt: Improved Potency VII, Spell Penetration VII, Lawful only (DC 24) (Blue Dragon)
 * Bronze Ingot Arcanum - +2 Quarterstaff: Superior Acid Lore, Superior Corrosion IV (Black Dragon chest)
 * Bulwark of Storm's Fist - +3 Heavy Steel Shield: +5 Constitution (White Dragon)
 * Copper Ingot Arcanum - +2 Quarterstaff: Superior Lightning Lore, Superior Magnetism IV (White Dragon chest)
 * Giantcrafted Siberys Compass - Trinket: +13 Search, +2 Resistance, +4 Will Save (Blue Dragon chest)
 * Globe of Imperial Blood - Trinket: +2 to all stats, Wizardy II (Black Dragon chest)
 * Gloves of the Forgotten Craft - Gloves: +13 Disable Device, +3 Dexterity, Weapon Focus: Thrown (White Dragon chest)
 * Great Axe of the Chained Soldier - +5 Greataxe, Immunity to Fear, Break Enhancement (level 12 caster) 1/rest
 * Hammer of the Leaden Clouds - +4 Warhammer: Thundering, Weighted 4%, Superior Sonic Lore, Greater Resonance IV (Blue Dragon chest)
 * Helm of the Black Dragon - Helm: +5 Dexterity, Black Dragon Bolt 1/day (Black Dragon chest)
 * Helm of the White Dragon - Helm: +5 Strength, Cone of Cold 1/rest (White Dragon chest)
 * Helm of the Blue Dragon - Helm: +5 Intelligence, Lightning Bolt 1/day (Blue Dragon chest)
 * Intricate Field Optics - Goggles: +13 Spot, +2 Wisdom, Continuous Detect Secret Doors (White Dragon)
 * Jorgundal's Collar - Necklace: Melee Alacrity 10% (White Dragon)
 * Madstone Rod - +1 Club: Dispel Madstone Effects 50 charges (Wizard, Sorcerer, Bard only) (drops after every Dragon Fight)
 * Manacles of Ceaseless Toil - Bracers: +3 Strength, +3 Constitution, Remove Exhaustion 3/rest (Black Dragon)
 * Mantle of the Dragonfriend - Cloak: +5 Charisma, +7 Diplomacy
 * Ring of Stormreaver Prophecy - Ring:+5 Wisdom, +2 Resistance
 * Silver Ingot Arcanum - +2 Quarterstaff: Superior Ice Lore, Superior Glaciation IV (Blue Dragon chest)
 * Skyvault Shield - +4 Heavy Shield, Mithral, Twilight
 * Tortured Livewood Longbow - +5 Longbow: Acid Arrow (Black Dragon chest)

The Grey Moon's Den: Extermination (Grey Moon Waning 4) (Grey Moon Waning 4) Loot

 * Sickle of Sypheros - +1 Sickle: Frost

Gwylan's Stand Loot

 * Gwylan's Blade - +1 Short sword: Perform +2, Roaring
 * Giant Stalker's Knife - +1 Kukri: Greater Giant bane (Confirmed fixed, and retroactive per these release notes )
 * Minotaur hair belt - Belt: +5 Balance
 * Phiarlan Ring - Ring: +5 Perform
 * Roguebane Breastplate - +1 Breastplate: Light Fortification
 * Thuranni Stalker's Mail - +2 Chainmail
 * Barbarian's Spirit - Bracers: Rage 1/rest

Haywire Foundry Loot (Vault of Night 4)

 * Bloodrage Symbiont - Trinket: Rage 3x/rest, Immunity to poison, Immunity to disease, Damage reduction 5/-, -2 Constitution, -2 Will save.
 * Lightning Rod (Guaranteed at end of VoN 4) - +1 Quarterstaff: Shocking, Greater Magnetism III, Lesser Lightning Resistance

Invaders Loot
The special Invaders item will show up randomly in the final boss's chest, and is determined by what kind of monster the boss is. (Note that the combination of Cold Iron and Pure Good/Holy is the only way to defeat the Damage Reduction of a Flesh Render, Fire Reaver, or Ice Flenser). Additionally, 2-5 Outsider Tokens will be in that chest, which can eventually be traded to a collector for items (in quantities of 25, apparently).
 * Beholder Optic Nerve - Necklace: +7 Spot, +7 Search, Beholder Ray Absorption 8x/rest
 * Garzuul's Bane - +3 Greataxe: Holy, Cold Iron
 * Prysuul's Bane - +4 Bastard sword: Pure Good, Cold Iron
 * Tharkuul's Bane - +3 Sickle: Holy, Cold Iron
 * Tyrzza's Bane - +3 Rapier: Pure Good, True Law, Cold Iron (The original item of this name was +4 Pure Good Cold Iron, and pre-existing items were not removed or changed)

Outsider Tokens Collectible Rewards

 * Demonic Breastplate - +5 Breastplate: Admantine, Fire Resistance, Ice Resistance
 * Docent of Defense - +5 Docent: Heavy Fortification, +2 Protection
 * Ring of Balance - Ring: Stability, +2 Natural Armor Bonus, Balance +13, Dismissal 3/day
 * Sceptor of Healing - +4 Heavy mace: Flametouched Iron, Greater Devotion V, Greater Healing Lore

Irestone Inlet Loot

 * Skartongue's Ladel - +1 Light mace: Shocking touch
 * Mutiny's Tooth - +1 Dagger: Acid touch
 * Hobble's Crossbow - +1 Heavy Repeating Crossbow: Cold touch

Kobold's New Ringleader Loot

 * Bloodknuckle's Loincloth Waistband - Belt: Light Fortification
 * Bloodknuckle's Smasher - +1 Maul
 * Brakhash's Axe - +1 Battleaxe
 * Grundok's Boots - Boots: +1 Jump
 * Madoorah's Vest -- +1 Leather Armor
 * Bronkarz's Cloak -- Cloak: +1 Will save

The Madstone Crater Loot

 * Ancient Band - Ring: Heavy Fortification, Protection +3

Offering of Blood Loot

 * Ward of Death - +2 Heavy Shield: Ghost Touch, Flaming, Undeadbane
 * Vulkoorim Fighting Leather - +5 Leather Armor: Lesser Fire Resistance, Hide +5
 * Ancient Vulkoorim Dagger - +4 Dagger: Greater Giantbane, Giant-Slaying

The Pit Loot

 * Muckdoom - +2 Club: Glass Ooze bane
 * Robe of Acid - Robe: Conjuration Focus, Superior Corrosion IV, Acid Resistance
 * Docent of Acid - +3 Docent: Conjuration Focus, Superior Corrosion IV, Acid Resistance

Prison of the Planes Loot

 * Charoush's Inferno - +5 Bastard Sword: Flaming burst (Fernia room)
 * Spiked Boots - Boots: +7 Balance, Immunity to Slippery Surfaces (Risia Room)
 * Kardin's Eye - Trinket: +5 Resistance (Xorian room)

Redwillow's Ruins Loot

 * Cloak of Troll's Resistance - Cloak: Lesser Cold Resistance, Lesser Sonic Resistance, Lesser Lightning Resistance
 * Drow Hunter Armor - +4 Studded leather
 * Flamedagger - +1 Dagger: Flaming, Burning hands 3/rest
 * Granite Plate - Half plate, Damage reduction 2/-
 * Maul of Might - +1 Maul: Force
 * Poison-Tipped Crossbow - +3 Light crossbow: Poison
 * Ring of Trollish Regeneration - Ring: Minor Regeneration, Protection +2
 * (This item has been removed from game and no longer drops, per this post by Graal (DDO Developer))
 * Scorpion Tail - +2 Shortbow: Poison
 * Tkorcha Family Scimitar - +3 Keen Scimitar
 * Twig of the Giant Mage - +1 Quarterstaff: Spell Resistance 15

Retrieve The Stolen Goods (Man Named Baudry Cartamon 3) Loot

 * Sword of Pain - +1 Short sword: Acid touch
 * Boots of the Long Step - Boots: +5% Striding

Sands of Menechatarum Loot

 * Hyena-claw Necklace - Necklace: +3 Constitution, +7 Intimidate (Stinkpelt chest)
 * Stinkpelt's Hide - +5 Hide Armor, -1 Charisma (Stinkpelt chest)
 * Whirlwind - +5 Greatsword: Screaming Telekinetic (Den Mother Fheena chest)
 * Wolf Whistle - Necklace: Charm Monster 3x/rest caster level 12 on nonmagical dogs only (Den Mother Fheena chest)
 * Zephyr - +3 Short sword: Finesse (Yrrush The Swift chest)
 * Robe of Fire - Robe: Superior Combustion III, Spell Focus Evocation (Thumok the Mad chest)
 * Mummy Wraps - +4 Padded Armor: Fearsome (Thumok the Mad chest)
 * Dynastic Falcata - +4 Khopesh: Adamantine, True Law, Charisma +2 (chest near General Thanak)
 * Flint - +4 Dagger : Shocking burst (Fire-dancer chest)
 * Bow of the Elements - +4 Longbow: Shocking burst, +2 Dexterity (Whirling Ozann chest)
 * Bloodstone - Trinket: Seeker +6 (Thirsty One chest)
 * Vulkoorim Pendant - Necklace: Improved Devotion II, Superior Nullification II, Taint of Evil (Volrune chest)
 * Vulkoorim Dervish Robe - Robe: +4 armor bonus, Lesser Fire Resistance (Mendexethazz Chest)
 * Shield of the Scorpion - +4 Heavy Shield: Spearblock (Wokran Kull chest)
 * Bracers of the Hunter- Bracers: Backstabbing +2, Reflex save +2, Hide +5 (Wokran Kull chest)
 * Mirage - +5 Scimitar - Ghost Touch, Deception (Utach Sandcrawl chest)
 * Sting - +4 Short sword - Poisonous (DC 17 Fort save or 1d4/1d4 con (Utach Sandcrawl chest)
 * Xuun - +3 Falchion - Flaming (Vorvand Darkfur chest)

Sewer Rescue Loot

 * Trogskull Helmet - Helm: Resistance + 1

The Shadow Crypt Loot

 * Tenebrous Stiletto - +4 Dagger: Adamantine, Ghost Touch, Deception, Hide +7
 * Phase Hammer - +3 Maul: Adamantine, Ghost Touch, Greater Incorporeal Bane
 * Dusk - +4 Docent, 10% Blurry
 * Shards of Light - 50 +3 Arrows: Cure Moderate Wounds, 75% Returning
 * Witching Hour - +2 Quarterstaff: Adamantine, Ghost Touch, Superior Nullification V, Greater Void Lore
 * Cloak of Protection - Cloak: Protection +3, Spell Resistance 17

Slavers of the Shrieking Mines Loot

 * Shrieking Star - +2 Morningstar: Roaring, Soundburst 1x/rest (locked chest)
 * Resonant Armor - +4 Studded Leather Armor: Sonic Guard, Lesser Sonic Resistance, Move Silently -5
 * Ring of the Ancestors - Ring: Raise Dead 1x/rest, required alignment: Good

Smuggler's Warehouse Loot

 * Chiku's Bauble - Trinket: Heal +3
 * Chitin Shield - +1 Light steel shield

Stealthy Repossession Loot

 * Gilk's Bangle - Trinket: +2 Will save
 * Jeeka's Spangle - Trinket: +2 Armor bonus
 * Neecha's Bead - Trinket: +2 Fortitude save
 * Wazul's Amulet - Necklace: +2 Reflex save

Stormcleave Outpost Loot

 * Lesser Boots of Striding and Springing - Boots: +10% Striding, +5 Jump
 * Onyxhorn - +2 Dagger: Finesse
 * Robe of Winter - Robe: Improved Fire Resistance
 * Helm of Flame - Helm: Power II, Improved Devotion II
 * Giant's Roar - +2 Longbow: Roaring
 * Essence of the Scout - +2 Docent: Silent moves
 * Nuushmaar's Adamantine Tooth - +2 Rapier: Adamantine
 * Iron Cleaver - +1 Battleaxe: Acid burst

The Swiped Signet Loot

 * Ruined Signet Brooch - Trinket: Heal +1

Tempest's Spine Loot

 * Maelstrom - +1 Greataxe: Anarchic, Frost
 * Choker of the Silver Tongue - Necklace: +5 Diplomacy, +5 Bluff
 * Star of Irian - +2 Morningstar: Righteous, Holy
 * Goggles of Perception - Goggles: +5 Spot, +5 Search
 * Platemail of Giants - +2 Full plate: Damage reduction 5/-
 * Shining Adamantine Plate - +2 Full plate: Adamantine, Immunity to poison, Command
 * Robe of Arcane Power - Robe: Potency IV
 * Eternal Wand of Charm Monster - Wand: Charm monster 2/rest, UMD DC: 6
 * Mithral Breastplate of the Elements - +1 Breastplate: Mithral, Cold resistance, Fire resistance

The Xorian Cipher Loot

 * Reaver's Ring - Ring: Light Fortification, Immunity to fear, -2 Will save
 * Planar Gird - Belt: Greater Heroism 1x/rest, Continuous Protection from chaos
 * Sign of Xoriat - Necklace: Shout 3x/rest, Spot +7, -2 Will save, Required Trait: Chaotic or UMD 20
 * Chaosgarde - Bracers: Continuous Protection from chaos, +2 Dodge bonus, Required Trait: Lawful or UMD 20
 * Chaos Band - Ring: Intelligence +3, Power III, -2 Will save
 * Thaarak Fang - Trinket: Immunity to poison, +2 Constitution, -2 Will save

Relic of a Sovereign Past Rewards
You must pay Adamantine ore to forge these items (Each instance has 15 of them).
 * Nightforge Armbands - Bracers: Improved False Life, Heroism 3/rest (10 ore)
 * Nightforge Darkhelm - Helm: +2 Wisdom, +5 Will save, Protection from Evil 3/rest (10 ore)
 * Nightforge Gorget - Necklace: Heavy Fortification (10 ore)
 * Nightforge Docent - +5 Docent, False Life (12 ore)
 * Nightforge Plate - +5 Full plate, Admantine (15 ore)

Elven Relics

 * Elf Relic Light Armor - +3 Chain shirt: Mithral, Minor Spell Penetration VI

Giant Relics

 * Giantcrafted Plate Armor - +5 Full plate: Admantine, Light Fortification, Shield 3/rest

Dragon Relics

 * Dragoncrafted Robe - Robe: +4 Armor Bonus, Conjuration Focus, WizardryIII

Dragon Scales Collecible Rewards

 * Black Dragonplate Armor - +5 Full plate: (9 base armor), Sacred, Wizardry V, Greater Acid Resistance, Undead Guard
 * Black Dragonscale Robe - Robe: +5 Armor Bonus, Wizardry V, Greater Evocation Focus, Greater Acid Resistance
 * Blue Dragonplate Armor - +5 Full plate: (9 base armor), Potency VII, Greater Arcane Lore, Spell Penetration VII, Greater Lightning Resistance
 * Blue Dragonscale Robe - Robe: +4 Armor Bonus, Potency VII, Greater Arcane Lore, Spell Penetration VII, Greater Lightning Resistance
 * White Dragonplate Armor - +5 Full plate: (9 base armor), Moderate Fortification, +4 Protection, Greater Cold Resistance, Shield 3/rest
 * White Dragonscale Robe - Robe: +6 Armor Bonus, Moderate Fortification, +4 Protection, Greater Cold Resistance, Shield 3/rest

Unique Items with Unknown or Non-Unique Locations

 * Boots of Speed- Boots, Haste 2/rest
 * Bottle of Air - Trinket: Underwater action
 * Dark Blue Ioun Stone - Trinket: Listen +3, Spot +3
 * Dusty Rose Ioun Stone - Trinket: +1 Protection
 * Dwarven Thrower - +2 Throwing axe: Returning, +2d6 dmg vs Giants, +1d6 dmg vs Non-Giants
 * Enchanted Darkleaf Banded Armor - +1 Banded mail, Darkleaf, Resistance +4
 * Flametongue - +1 Longsword: Flaming burst, Scorching ray 1/rest
 * Frostbrand - +3 Greatsword: Frost, Fire resistance
 * Keoghtom's Ointment - Trinket: Keoghtom's Ointment (5 charges)
 * Luck Blade - +2 Short sword: Resistance +1
 * Mace of Smiting - +3 Heavy mace: Adamantine, Smiting
 * Mithral full plate of speed - +1 Full plate: Mithral, Haste 2/rest
 * Murlynd's Spoon - Trinket: Murlynd's Spoon 1/rest
 * Pale Green Ioun Stone - Trinket: +2 Strength
 * Pearl of the Sirines - Trinket: Underwater action, Swim +10
 * Pink Ioun Stone - Trinket: +2 Constitution
 * Pink and Blue Ioun Stone - Trinket: +2 Charisma
 * Robe of the Magi - Robe: Magi
 * Scarab of Spell Absorption - Trinket: Absorbs up to 50 spell levels
 * Scarlet and Blue Ioun Stone - Trinket: +2 Intelligence
 * Stone of Good Luck - Trinket: Good luck
 * Sunblade - +2 Short sword (1d10 slashing dmg): Flametouched iron, Evil bane, extra 1d10 + 2 dmg vs. Undead
 * Swift Demise - +1 Heavy crossbow: Crippling