Disease

Diseases can generally attack your ability scores over time, diminishing your fighting ability to leave you helpless. They may also leave you blinded.

Diseases are either natural, magical, or supernatural.

Diseases differ from curses in that they are often the effect of a physical act or touch.

When you are exposed to a disease, your character makes a saving throw vs. the disease's difficulty class. Your character will have a modifier to this saving throw derived from your class levels and your race, potentially modified by what enhancements and feats you have taken, as well as whatever buffs have been cast on you, and what equipment you are wearing. Proof Against Disease effects on items make you completely immune to natural diseases, and also grant bonuses to saving throws against magical diseases, and the wearer will not fail saves against them on a natural 1.

All Diseases are permanent until removed. They usually offer a recurring save every 60 seconds. However the first save will only negate the relevant effects of the disease, and not remove it. You must save consecutively twice in a row to rid yourself of a disease.

Notes:
 * Mummy Rot is both a supernatural disease and a supernatural curse. It will kill the character unless both effects are removed and in the right order.
 * Warforged are immune to ability score damage from natural diseases, except those that specifically affect wood or metal, and get a +10 to saves vs magical diseases, and do not fail saving throws against them on a natural 1.
 * Paladins are granted immunity to all diseases at level 3 with the granted feat Divine Health.
 * Monks are granted immunity to all natural diseases at level 5 with the granted feat Purity of Body.
 * Aside from saving against the affliction twice, diseases can be removed by the Remove Disease spell or potion, or the Monk spell-like ability, The Receptive Earth.

List of Diseases
Diseases